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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS1
All Species:
27.88
Human Site:
T614
Identified Species:
87.62
UniProt:
Q07889
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07889
NP_005624.2
1333
152464
T614
I
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
T879
I
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Rhesus Macaque
Macaca mulatta
XP_001103238
1312
149667
T589
I
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Dog
Lupus familis
XP_540157
1342
152915
T623
I
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Cat
Felis silvestris
Mouse
Mus musculus
Q62245
1319
150865
T614
L
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509981
1303
148422
T610
L
E
R
M
L
D
V
T
M
L
Q
E
E
K
E
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
T654
C
K
L
I
E
R
L
T
Y
H
I
Y
A
D
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
T612
F
K
L
I
E
R
L
T
Y
H
R
Y
A
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.3
95.7
96.8
N.A.
96.6
N.A.
N.A.
87.4
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
N.A.
50.5
Protein Similarity:
100
83.4
96.3
97.6
N.A.
97.9
N.A.
N.A.
90.3
N.A.
N.A.
N.A.
N.A.
56.6
N.A.
N.A.
67.7
P-Site Identity:
100
100
100
100
N.A.
93.3
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
93.3
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
88
0
0
% A
% Cys:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
13
0
0
0
0
0
0
0
88
0
% D
% Glu:
0
13
0
0
88
0
0
0
0
0
0
13
13
0
13
% E
% Phe:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
88
0
0
0
0
0
% H
% Ile:
50
0
0
88
0
0
0
0
0
0
13
0
0
0
0
% I
% Lys:
0
88
0
0
0
0
0
0
0
0
0
0
0
13
0
% K
% Leu:
25
0
88
0
13
0
88
0
0
13
0
0
0
0
0
% L
% Met:
0
0
0
13
0
0
0
0
13
0
63
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
88
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% Q
% Arg:
0
0
13
0
0
88
0
0
0
0
13
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
88
0
0
88
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _